Technology Process of tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate oxalate
There total 4 articles about tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate oxalate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-benzyl-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl ester;
With
10 wt% Pd(OH)2 on carbon; hydrogen;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Green chemistry;
oxalic acid;
In
methanol; ethyl acetate;
Solvent;
Green chemistry;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; ethanol / 0.5 h / Green chemistry
1.2: 12 h / 20 °C / Green chemistry
2.1: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 20 °C / Green chemistry
2.2: Green chemistry
With
10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydroxide;
In
tetrahydrofuran; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetonitrile / 1.25 h / 10 - 50 °C / Cooling with ice; Green chemistry
1.2: 6 h / 80 °C / Green chemistry
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 20 h / 0 °C / Reflux; Green chemistry
3.1: sodium hydroxide / water; ethanol / 0.5 h / Green chemistry
3.2: 12 h / 20 °C / Green chemistry
4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 20 °C / Green chemistry
4.2: Green chemistry
With
sodium tetrahydroborate; 10 wt% Pd(OH)2 on carbon; boron trifluoride diethyl etherate; hydrogen; sodium hydroxide;
In
tetrahydrofuran; ethanol; water; acetonitrile;
