N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Base Information

Chemical Name:N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
CAS No.:1800025-30-2
Molecular Formula:C₂₇H₂₁ClF₅N₇O₃S
Molecular Weight:654.02
Hs Code.:

N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

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Suppliers and Price of N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

There total 10 articles about N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 344591-91-9
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid

: 1-(5-bromopyrimidin-2-yl)-N-(4-chloro-2,6-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

: 1800025-30-2
N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; for 6h; Reflux;
DOI:10.1016/j.bmc.2015.06.003

Reference yield:

: benzyl 5-(chlorosulfonyl)-7-nitro-2,3-dihydro-1H-indole-1-carboxylate

: 1800025-30-2
N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: 2,2,2-trifluoroethanol / 24 h / Molecular sieve; Reflux

2: zinc; acetic acid / 13 h / 20 °C / Inert atmosphere

3: N,N-dimethyl acetamide / 0 - 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

5: water; sodium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C / Inert atmosphere

6: tetrahydrofuran / Reflux

7: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 760.05 Torr

8: n-Amyl nitrite; copper(ll) bromide / acetonitrile / 2.5 h / 0 - 60 °C

9: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 6 h / Reflux

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-Amyl nitrite; water; hydrogen; sodium hydride; potassium carbonate; acetic acid; sodium hydroxide; copper(ll) bromide; zinc; In tetrahydrofuran; methanol; ethanol; 2,2,2-trifluoroethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile; mineral oil; 8: |Sandmeyer Reaction / 9: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2015.06.003

Reference yield:

: 69411-06-9
2,6-difluoro-4-chloroaniline

: 1800025-30-2
N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: 2,2,2-trifluoroethanol / 24 h / Molecular sieve; Reflux

2: zinc; acetic acid / 13 h / 20 °C / Inert atmosphere

3: N,N-dimethyl acetamide / 0 - 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

5: water; sodium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C / Inert atmosphere

6: tetrahydrofuran / Reflux

7: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 760.05 Torr

8: n-Amyl nitrite; copper(ll) bromide / acetonitrile / 2.5 h / 0 - 60 °C

9: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 6 h / Reflux

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-Amyl nitrite; water; hydrogen; sodium hydride; potassium carbonate; acetic acid; sodium hydroxide; copper(ll) bromide; zinc; In tetrahydrofuran; methanol; ethanol; 2,2,2-trifluoroethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile; mineral oil; 8: |Sandmeyer Reaction / 9: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2015.06.003