lefamulin acetate

Base Information

• Chemical Name: lefamulin acetate
• CAS No.: 1350636-82-6
• Molecular Formula: C₂H₄O₂*C₂₈H₄₅NO₅S
• Molecular Weight: 567.788
• Mol file: 1350636-82-6.mol

Synonyms:

Chemical Property of lefamulin acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Lefamulinacetate >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of lefamulin acetate

There total 20 articles about lefamulin acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pleuromutilin tosylate (31716-01-5) → lefamulin acetate (1350636-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

3.1: acetic acid methyl ester; water / 4.08 h / 0 - 55 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tert-butyl methyl ether; acetic acid methyl ester; water; isopropyl alcohol;

Reference yield:

(R)-cyclohex-3-enecarboxylic acid (5709-98-8) → lefamulin acetate (1350636-82-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.58 h / 20 - 95 °C / Reflux

2.1: copper(l) chloride / 0.83 h / 80 - 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 15 - 40 °C / Industry scale

4.1: tetrabutyl-ammonium chloride / toluene / 4 h / 30 - 45 °C / Industry scale

5.1: hydrazine hydrate; DL-dithiothreitol / dichloromethane / 3 h / 18 - 22 °C / Industry scale

6.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

7.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

7.2: 1.5 h / 0 - 25 °C / Industry scale

8.1: acetic acid methyl ester; water / 4.08 h / 0 - 55 °C

With DL-dithiothreitol; phosphoric acid; diphenyl phosphoryl azide; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; tetrabutyl-ammonium chloride; benzyltri(n-butyl)ammonium chloride; copper(l) chloride; In dichloromethane; tert-butyl methyl ether; acetic acid methyl ester; water; isopropyl alcohol; toluene; 1.1: Curtius Rearrangement;

Reference yield:

pleuromutilin → lefamulin acetate (1350636-82-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

3.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

3.2: 1.5 h / 0 - 25 °C / Industry scale

4.1: acetic acid methyl ester; water / 4.08 h / 0 - 55 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; acetic acid methyl ester; water; isopropyl alcohol;

upstream raw materials:

14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

acetic acid

(R)-cyclohex-3-enecarboxylic acid

pleuromutilin tosylate