tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

Base Information

Chemical Name:tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate
CAS No.:1338091-30-7
Molecular Formula:C₁₂H₁₄FNO₃
Molecular Weight:239.246
Hs Code.:

Synonyms:

Suppliers and Price of tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl3-(3-fluoropyridin-2-yl)-3-oxopropanoate 97%
1g
$ 842.00

Total 1 raw suppliers

Chemical Property of tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(3-fluoropyridin-2-yl)-3-oxopropanoate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

There total 2 articles about tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869108-35-0
methyl 3-fluoropyridine-2-carboxylate

: 540-88-5
acetic acid tert-butyl ester

: 1338091-30-7
tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

Guidance literature:: acetic acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; at -78 ℃; for 0.75h;

methyl 3-fluoropyridine-2-carboxylate; In tetrahydrofuran; n-heptane; at -78 ℃; for 2h;

Reference yield:

: lithium 3-fluoropyridine-2-carboxylate

: 1338091-30-7
tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran / 0.75 h / -78 °C

2.2: 2 h / -78 °C

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane;

Reference yield:

: 1338091-30-7
tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

: 1338091-06-7
C₁₆H₁₄FN₅O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; 4-acetamidobenzenesulfonyl azide / acetonitrile / 0 - 20 °C

2.1: trimethylphosphane / tetrahydrofuran / 20 °C

2.2: 0.25 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dimethyl sulfoxide / 16 h / 20 °C

6.1: hydroxylamine hydrochloride; titanium(IV) isopropylate / toluene / 72 h / Reflux

With titanium(IV) isopropylate; 4-acetamidobenzenesulfonyl azide; hydroxylamine hydrochloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; trimethylphosphane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;