3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 869108-35-0
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.13
• Hs Code.: 2933399090
• Mol file: 869108-35-0.mol

Synonyms:methyl 3-fluoropyridine-2-carboxylate

Chemical Property of 3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0719mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 228.8 °C at 760 mmHg
• Flash Point: 92.2 °C
• PSA: 39.19000
• Density: 1.243 g/cm³
• LogP: 1.00730
• Storage Temp.: Room temperature.

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-fluoropicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

There total 4 articles about 3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanol (67-56-1) + 1,2-dimethoxypropane (7778-85-0) + lithium 3-fluoropyridine-2-carboxylate → methyl 3-fluoropyridine-2-carboxylate (869108-35-0)

Guidance literature:

With sulfuric acid; for 20h; Reflux;

Reference yield:

dimethyl sulfate (77-78-1) + 3-fluoro(pyridin-2-yl)carboxylic acid (152126-31-3) → methyl 3-fluoropyridine-2-carboxylate (869108-35-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.114087

Reference yield:

3-fluoro(pyridin-2-yl)carboxylic acid (152126-31-3) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 3-fluoropyridine-2-carboxylate (869108-35-0)

Guidance literature:

In methanol; hexane; benzene; at 20 ℃; for 0.5h;

upstream raw materials:

3-fluoro(pyridin-2-yl)carboxylic acid

diazomethyl-trimethyl-silane

methanol

1,2-dimethoxypropane

Downstream raw materials:

tert-butyl 3-(3-fluoropyridin-2-yl)-3-oxopropanoate

C₁₆H₁₄FN₅O₂

C₁₆H₁₃FN₄O₂

C₁₇H₁₃FN₆O₂

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