N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester
CAS No.:351359-01-8
Molecular Formula:C₂₅H₃₇ClFN₅O₅
Molecular Weight:542.051
Hs Code.:

<i>N</i>'-{4-[3-(<i>tert</i>-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid <i>tert</i>-butyl ester

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Chemical Property of N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

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Technology Process of N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

There total 5 articles about N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351354-33-1
3-chloro-2,4,5-trifluoro-benzoic acid ethyl ester

: 351359-01-8
N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TEA / acetonitrile

2: dimethylsulfoxide / 100 °C

3: aq. NaOH / tetrahydrofuran; methanol / 60 °C

4: EDCI / CH₂Cl₂

With sodium hydroxide; TEA; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.005

Reference yield:

: 4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2,5-difluoro-benzoic acid ethyl ester

: 351359-01-8
N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfoxide / 100 °C

2: aq. NaOH / tetrahydrofuran; methanol / 60 °C

3: EDCI / CH₂Cl₂

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2006.12.005

Reference yield:

: 4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoic acid ethyl ester

: 351359-01-8
N'-{4-[3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidin-1-yl]-3-chloro-2-cyclopropylamino-5-fluoro-benzoyl}-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / tetrahydrofuran; methanol / 60 °C

2: EDCI / CH₂Cl₂

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.12.005