2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Base Information

Chemical Name:2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan
CAS No.:1319803-89-8
Molecular Formula:C₄₀H₃₇NO₇
Molecular Weight:643.736
Hs Code.:

Synonyms:

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Chemical Property of 2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

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Technology Process of 2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

There total 6 articles about 2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 201230-82-2
carbon monoxide

: 1319803-88-7
3-N,N-dibenzylamino-4-methoxy-phenylacetylene

: 41046-70-2
2-iodo-5-methoxyphenol

: 1319803-89-8
2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Guidance literature:: 3-N,N-dibenzylamino-4-methoxy-phenylacetylene; 2-iodo-5-methoxyphenol; With bis-triphenylphosphine-palladium(II) chloride; methylmagnesium chloride; In tetrahydrofuran; at 0 - 65 ℃; Inert atmosphere;

5-iodo-1,2,3-trimethoxybenzene; carbon monoxide; In dimethyl sulfoxide; at 80 ℃;
DOI:10.1021/jm200454y

Reference yield:

: 1319804-08-4
2-methoxy-4-iodo-N,N-dibenzylaniline

: 1319803-89-8
2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2.1: potassium fluoride / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; methylmagnesium chloride / tetrahydrofuran / 0 - 65 °C / Inert atmosphere

3.2: 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; methylmagnesium chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200454y

Reference yield:

: 100-39-0
benzyl bromide

: 1319803-89-8
2-(3-N,N-dibenzyl-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6.5 h / 100 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: potassium fluoride / tetrahydrofuran; methanol / 1 h / 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; methylmagnesium chloride / tetrahydrofuran / 0 - 65 °C / Inert atmosphere

4.2: 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; methylmagnesium chloride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200454y