Technology Process of DL-(1/2,3,4,6)-3,4-diacetamido-6-acetoxymethyl-1,2-di-O-acetyl-1,2-cyclohexanediol
There total 32 articles about DL-(1/2,3,4,6)-3,4-diacetamido-6-acetoxymethyl-1,2-di-O-acetyl-1,2-cyclohexanediol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 9 steps
1: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature
2: 72 percent / m-chloroperoxybenzoic acid, phosphate buffer pH 8 / 1,2-dichloro-ethane / 4 h / Ambient temperature
3: 44 percent / NaN3 / dimethylformamide; H2O / 24 h / 100 °C
4: 100 percent / pyridine / 1 h / Ambient temperature
5: 81 percent / LiAlH4 / tetrahydrofuran / 0.75 h / 0 °C
6: 100 percent / pyridine
7: 99 percent / NaN3 / dimethylformamide / 1.5 h / 100 °C
8: 71 percent / hydrogen / Raney nickel T-4 / ethyl acetate; ethanol
9: 1) cyclohexene, 2) pyridine / 1) 20percent Pd(OH)2-C / 1) EtOH, reflux, overnight
With
pyridine; lithium aluminium tetrahydride; sodium azide; phosphate buffer pH 8; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; cyclohexene;
palladium hydroxide - carbon; Raney nickel T-4;
In
tetrahydrofuran; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(90)84020-U
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature
2: 17 percent / m-chloroperoxybenzoic acid, phosphate buffer pH 8 / 1,2-dichloro-ethane / 4 h / Ambient temperature
3: 86 percent / NaN3 / dimethylformamide; H2O / 2 h / 100 °C
4: 92 percent / pyridine / 1,2-dichloro-ethane / 0.17 h / -15 °C
5: 97 percent / NaN3 / dimethylformamide / 1 h / Ambient temperature
6: 1) Ph3P, 2) pyridine / 1) CH2Cl2, water, r.t, overnight
7: 1) cyclohexene, 2) pyridine / 1) 20percent Pd(OH)2-C / 1) EtOH, reflux, overnight
With
pyridine; sodium azide; phosphate buffer pH 8; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; cyclohexene;
palladium hydroxide - carbon;
In
water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(90)84020-U
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature
2: 17 percent / m-chloroperoxybenzoic acid, phosphate buffer pH 8 / 1,2-dichloro-ethane / 4 h / Ambient temperature
3: 86 percent / NaN3 / dimethylformamide; H2O / 2 h / 100 °C
4: 93 percent / dimethylformamide / Ambient temperature
5: 1) LiAlH4, 2) pyridine / 1) THF, 45 min, 0 deg C
6: 51 percent / NaN3 / dimethylformamide / 4 h / 100 °C
7: 99 percent / hydrogen / Raney nickel T-4 / ethyl acetate; ethanol
8: 1) cyclohexene, 2) pyridine / 20percent Pd(OH)2-C / 1) EtOH, reflux, overnight
With
pyridine; lithium aluminium tetrahydride; sodium azide; phosphate buffer pH 8; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; cyclohexene;
palladium hydroxide - carbon; Raney nickel T-4;
In
ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(90)84020-U
