DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

Base Information

Chemical Name:DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol
CAS No.:131291-40-2
Molecular Formula:C₇H₁₆N₂O₃
Molecular Weight:176.216
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

Chemical Property:

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Technology Process of DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

There total 36 articles about DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 131291-51-5,131349-57-0,131349-58-1,131351-53-6
DL-(1,3,4/2,6)-3,4-diacetamido-6-acetoxymethyl-1,2-di-O-acetyl-1,2-cyclohexanediol

: 131291-40-2,131349-49-0,131349-50-3,131349-51-4
DL-(1,3,4/2,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

Guidance literature:: With hydrogenchloride; at 115 ℃; for 6h;
DOI:10.1016/0008-6215(90)84020-U

Reference yield:

: 130970-84-2,143058-81-5
DL-(1,3/2)-1,2-dihydroxy-3-hydroxymethyl-5-cyclohexene

: 131291-40-2,131349-49-0,131349-50-3,131349-51-4
DL-(1,4/2,3,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

2: 72 percent / m-chloroperoxybenzoic acid, phosphate buffer pH 8 / 1,2-dichloro-ethane / 4 h / Ambient temperature

3: 44 percent / NaN₃ / dimethylformamide; H₂O / 24 h / 100 °C

4: 100 percent / pyridine / 1 h / Ambient temperature

5: 81 percent / LiAlH₄ / tetrahydrofuran / 0.75 h / 0 °C

6: 100 percent / pyridine

7: 99 percent / NaN₃ / dimethylformamide / 1.5 h / 100 °C

8: 71 percent / hydrogen / Raney nickel T-4 / ethyl acetate; ethanol

9: 1) cyclohexene, 2) pyridine / 1) 20percent Pd(OH)2-C / 1) EtOH, reflux, overnight

10: M HCl / Heating

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; phosphate buffer pH 8; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; cyclohexene; palladium hydroxide - carbon; Raney nickel T-4; In tetrahydrofuran; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(90)84020-U

Reference yield:

: 130970-84-2,143058-81-5
DL-(1,3/2)-1,2-dihydroxy-3-hydroxymethyl-5-cyclohexene

: 131291-40-2,131349-49-0,131349-50-3,131349-51-4
DL-(1/2,3,4,6)-3,4-diamino-6-hydroxymethyl-1,2-cyclohexanediol

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / NaH / dimethylformamide / 2 h / Ambient temperature

2: 72 percent / m-chloroperoxybenzoic acid, phosphate buffer pH 8 / 1,2-dichloro-ethane / 4 h / Ambient temperature

3: 48 percent / NaN₃ / dimethylformamide; H₂O / 24 h / 100 °C

4: 88 percent / pyridine / Ambient temperature

5: 90 percent / NaN₃ / dimethylformamide / 100 °C

6: 1) Ph₃P, water, 2) pyridine / 1) CH₂Cl₂, r.t.

7: 1) cyclohexene, 2) pyridine / 1) 20percent Pd(OH)2-C / 1) EtOH, reflux, overnight

8: M HCl / Heating

With pyridine; hydrogenchloride; sodium azide; phosphate buffer pH 8; water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; cyclohexene; palladium hydroxide - carbon; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(90)84020-U