L-Glutamic acid, N-[4-[1-[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6- yl)methyl]propyl]benzoyl]-

Base Information

Chemical Name:L-Glutamic acid, N-[4-[1-[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6- yl)methyl]propyl]benzoyl]-
CAS No.:105580-33-4
Molecular Formula:C23H29N5O6
Molecular Weight:471.513
Hs Code.:
Mol file:105580-33-4.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Glutamic acid, N-[4-[1-[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6- yl)methyl]propyl]benzoyl]-

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of L-Glutamic acid, N-[4-[1-[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6- yl)methyl]propyl]benzoyl]-

There total 11 articles about L-Glutamic acid, N-[4-[1-[(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6- yl)methyl]propyl]benzoyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 123751-81-5
2-{4-[1-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester; compound with trifluoro-acetic acid

: 105580-33-4
10-ethyl-5,6,7,8-tetrahydro-5,10-dideazafolic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 100 ℃; for 0.25h;
DOI:10.1021/jm00164a033

Reference yield:

: 2438-05-3
4-n-propylbenzoic acid

: 105580-33-4
10-ethyl-5,6,7,8-tetrahydro-5,10-dideazafolic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) LDA, HMPA / 1.) THF, hexane, a) 0-5 deg C, 6 h, b) RT temp., 22 h, 2.) 0-5 deg C

2: 28 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

3: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

4: K₂CO₃ / 0.67 h / 60 °C

5: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

6: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

7: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

8: 94 percent / 10percent NaOH / 2.5 h / Heating

9: 39 percent / ET₃N, isobutyl chloroformate / dimethylsulfoxide / 20 h / Ambient temperature

10: 25 percent / CF₃COOH, H₂ / PtO₂ / ethanol / 44 h / 760 Torr

11: 59 percent / 0.1N NaOH / ethanol / 0.25 h / 100 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; sodium hydroxide; water; hydrogen; sodium; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; isobutyl chloroformate; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a033

Reference yield:

: 123751-64-4
4-((E)-1-Ethyl-4-methoxy-but-3-enyl)-benzoic acid methyl ester

: 105580-33-4
10-ethyl-5,6,7,8-tetrahydro-5,10-dideazafolic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

2: K₂CO₃ / 0.67 h / 60 °C

3: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

4: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

5: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

6: 94 percent / 10percent NaOH / 2.5 h / Heating

7: 39 percent / ET₃N, isobutyl chloroformate / dimethylsulfoxide / 20 h / Ambient temperature

8: 25 percent / CF₃COOH, H₂ / PtO₂ / ethanol / 44 h / 760 Torr

9: 59 percent / 0.1N NaOH / ethanol / 0.25 h / 100 °C

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; water; hydrogen; sodium; potassium carbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00164a033