2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone

Base Information

• Chemical Name: 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone
• CAS No.: 142050-42-8
• Molecular Formula: C₁₆H₁₆O₅
• Molecular Weight: 294.276
• Mol file: 142050-42-8.mol

Synonyms:

Chemical Property of 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone

There total 6 articles about 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isovanillin (621-59-0) → 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone (142050-42-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaOEt / 1.) EtOH, 2.) reflux, 2 h

2: 100 percent / NaBH₄ / H₂O; ethanol / 1 h / 20 - 25 °C

3: 97 percent / SOCl₂, pyridine / diethyl ether / 0.5 h / below 5 deg C

4: 92 percent / KI, urea / acetone / 6 h / Heating

5: H₂ / 10percent Pd/C / acetone / 1 h / Ambient temperature

6: 81 percent / K₂CO₃ / acetone; toluene / 2.5 h / Heating

7: 1.) ZnCl₂, HCl, 2.) H₂O / 1.) Et₂O, 0-5 deg C

With pyridine; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; water; hydrogen; sodium ethanolate; potassium carbonate; urea; potassium iodide; zinc(II) chloride; palladium on activated charcoal; In diethyl ether; ethanol; water; acetone; toluene;

Reference yield:

3-benzyloxy-4-methoxy-benzyl alcohol (1860-60-2) → 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone (142050-42-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / SOCl₂, pyridine / diethyl ether / 0.5 h / below 5 deg C

2: 92 percent / KI, urea / acetone / 6 h / Heating

3: H₂ / 10percent Pd/C / acetone / 1 h / Ambient temperature

4: 81 percent / K₂CO₃ / acetone; toluene / 2.5 h / Heating

5: 1.) ZnCl₂, HCl, 2.) H₂O / 1.) Et₂O, 0-5 deg C

With pyridine; hydrogenchloride; thionyl chloride; water; hydrogen; potassium carbonate; urea; potassium iodide; zinc(II) chloride; palladium on activated charcoal; In diethyl ether; acetone; toluene;

Reference yield:

3-benzyloxy-4-methoxy-benzyl chloride (1699-38-3) → 2,4-dihydroxyphenyl <3-OCT3>3',4'-dimethoxybenzyl ketone (142050-42-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / KI, urea / acetone / 6 h / Heating

2: H₂ / 10percent Pd/C / acetone / 1 h / Ambient temperature

3: 81 percent / K₂CO₃ / acetone; toluene / 2.5 h / Heating

4: 1.) ZnCl₂, HCl, 2.) H₂O / 1.) Et₂O, 0-5 deg C

With hydrogenchloride; water; hydrogen; potassium carbonate; urea; potassium iodide; zinc(II) chloride; palladium on activated charcoal; In acetone; toluene;

upstream raw materials:

isovanillin

3-benzyloxy-4-methoxy-benzyl alcohol

3-benzyloxy-4-methoxy-benzyl chloride

2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile

Downstream raw materials:

7-hydroxy-<3'-OT3>3',4'-dimethoxyisoflavone