(3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

Base Information

Chemical Name:(3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol
CAS No.:140844-89-9
Molecular Formula:C₁₈H₃₀O₃Si
Molecular Weight:322.52
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

Chemical Property:

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Technology Process of (3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

There total 8 articles about (3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 140844-87-7
(R,Z)-6-t-butyldimethylsilyloxy-1-phenyl-1-hexen-3-ol

: 140844-89-9,140924-16-9
(3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

Guidance literature:: With sodium hydroxide; magnesium monoperoxyphthalate hexahydrate; In water; isopropyl alcohol; for 2h; Ambient temperature;

Reference yield:

: 6738-06-3
phenylethynylmagnesium bromide

: 140844-89-9,140924-16-9
(3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) ethyl chloroformate, triethylamine / 1.) toluene, -20 deg C, 2 h, 2.) THF, -40 deg C, 1 h

2: 86 percent / sodium borohydride / methanol / 1 h / Ambient temperature

3: diethyl ether / 48 h / 20 °C / pig pancreatic lipase

4: lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

5: imidazole / dimethylformamide / 1 h / 0 °C

6: 93 percent / monoperphthalic acid monomagnesium salt, 2 N sodium hydroxide / propan-2-ol; H₂O / 2 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; chloroformic acid ethyl ester; magnesium monoperoxyphthalate hexahydrate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 59700-84-4
4-oxo-6-phenyl-5-hexynoic acid methyl ester

: 140844-89-9,140924-16-9
(3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / sodium borohydride / methanol / 1 h / Ambient temperature

2: diethyl ether / 48 h / 20 °C / pig pancreatic lipase

3: lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

4: imidazole / dimethylformamide / 1 h / 0 °C

5: 93 percent / monoperphthalic acid monomagnesium salt, 2 N sodium hydroxide / propan-2-ol; H₂O / 2 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; isopropyl alcohol;