Technology Process of DL-4,5-di-0-benzyl-6-0-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1-(dibenzylphosphate)
There total 5 articles about DL-4,5-di-0-benzyl-6-0-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1-(dibenzylphosphate) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / H2 / 10percent Pd-C / ethanol / 2 h / Ambient temperature
2: 1.) NaH (60percent dispersion) / 1.) r. t., HMPA, 15 min 2.) a.) THF, 3h r. t. b.) 44h, 95 deg C
3: 1.) n-BuLi, diisopropylamine / 1.) hexanes, THF, -30 - -25 deg C, 20 min 2.) warm to 2 deg C over 4h
With
n-butyllithium; hydrogen; sodium hydride; diisopropylamine;
palladium on activated charcoal;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / 4 Angstroem molecular sieves / CHCl3 / 52 h / Heating
2: 88 percent / H2 / 10percent Pd-C / ethanol / 2 h / Ambient temperature
3: 1.) NaH (60percent dispersion) / 1.) r. t., HMPA, 15 min 2.) a.) THF, 3h r. t. b.) 44h, 95 deg C
4: 1.) n-BuLi, diisopropylamine / 1.) hexanes, THF, -30 - -25 deg C, 20 min 2.) warm to 2 deg C over 4h
With
n-butyllithium; 4 A molecular sieve; hydrogen; sodium hydride; diisopropylamine;
palladium on activated charcoal;
In
ethanol; chloroform;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH (60percent dispersion) / 1.) r. t., HMPA, 15 min 2.) a.) THF, 3h r. t. b.) 44h, 95 deg C
2: 1.) n-BuLi, diisopropylamine / 1.) hexanes, THF, -30 - -25 deg C, 20 min 2.) warm to 2 deg C over 4h
With
n-butyllithium; sodium hydride; diisopropylamine;
