Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester

Base Information

• Chemical Name: Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester
• CAS No.: 179030-50-3
• Molecular Formula: C₃₁H₄₇ClN₅O₈P
• Molecular Weight: 684.17
• Mol file: 179030-50-3.mol

Synonyms:

Chemical Property of Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester

There total 6 articles about Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester (179030-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, H₂O / acetonitrile / 0.17 h

2: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In acetonitrile;

DOI:10.1021/jm950777g

Reference yield:

Formic acid (R)-2-dodecyloxy-propyl ester → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester (179030-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: methanolic K₂CO₃ / Ambient temperature

2: pyridine, H₂O / acetonitrile / 0.17 h

3: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; potassium carbonate; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In acetonitrile;

DOI:10.1021/jm950777g

Reference yield:

(R)-2-Dodecyloxy-propan-1-ol (179030-45-6) → Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester (R)-2-dodecyloxy-propyl ester (179030-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, H₂O / acetonitrile / 0.17 h

2: pyridine, 1-(2-mesitylenesulfonyl)-3-nitro-1,2,4-triazole / 12 h / Ambient temperature

With pyridine; water; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In acetonitrile;

DOI:10.1021/jm950777g

upstream raw materials:

3'-azido-2',3'-deoxythymidine

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

(R)-2-Dodecyloxy-propan-1-ol

(R)-2-(dodecyloxy)-1-O-(triphenylmethyl)propane