N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

Base Information

Chemical Name:N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
CAS No.:1613293-06-3
Molecular Formula:C₄₃H₆₂BN₅O₅
Molecular Weight:739.807
Hs Code.:

N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

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Chemical Property of N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

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Technology Process of N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

There total 4 articles about N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1613293-06-3
N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine / methanol / 24 h / Reflux

3: sodium hydroxide / 2 h / Heating

4: toluene / 2 h / Reflux

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dibenzoyl peroxide; In methanol; tetrachloromethane; toluene;
DOI:10.1021/jm500352v

Reference yield:

: 83908-06-9
4-bromomethylsalicylic acid methyl ester

: 1613293-06-3
N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / methanol / 24 h / Reflux

2: sodium hydroxide / 2 h / Heating

3: toluene / 2 h / Reflux

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; toluene;
DOI:10.1021/jm500352v

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1613293-06-3
N-((S)-1-(((R)-1-(7-((hexadecylamino)methyl)-4-oxo-4H-benzo-[d][1,3,2]dioxaborinin-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 24 h / Reflux

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux

3: N-ethyl-N,N-diisopropylamine / methanol / 24 h / Reflux

4: sodium hydroxide / 2 h / Heating

5: toluene / 2 h / Reflux

With N-Bromosuccinimide; sulfuric acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dibenzoyl peroxide; In methanol; tetrachloromethane; toluene;
DOI:10.1021/jm500352v