(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide
CAS No.:1620069-08-0
Molecular Formula:C₃₀H₃₁F₃N₈O₃
Molecular Weight:608.623
Hs Code.:

(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

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Chemical Property of (S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

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Technology Process of (S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

There total 7 articles about (S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₆N₆O₄

: 1620069-08-0
(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; hydrogenchloride / ethanol; water

2: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; iron; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.030

Reference yield:

: (1H-imidazol-2-yl)(3-nitrophenyl)methanone

: 1620069-08-0
(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 3 h / 100 °C

2: 3-chloro-benzenecarboperoxoic acid / 2 h / 20 °C

3: 6 h / 60 °C

4: iron; hydrogenchloride / ethanol; water

5: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; iron; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.030

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1620069-08-0
(S)-N-(3-(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazole-2-carbonyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / pyridine / 0 - 20 °C

1.2: 1 h

2.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / 2 h / 20 °C

4.1: 6 h / 60 °C

5.1: iron; hydrogenchloride / ethanol; water

6.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; triethylamine / N,N-dimethyl-formamide

With hydrogenchloride; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; iron; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.030