5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide
CAS No.:1202921-19-4
Molecular Formula:C₁₈H₂₂ClN₃O₄
Molecular Weight:379.843
Hs Code.:

Synonyms:

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Chemical Property of 5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

Chemical Property:

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Technology Process of 5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

There total 6 articles about 5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₀ClN₃O₄

: 1202921-19-4
5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm201155e

Reference yield:

: 747413-05-4
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

: 1202921-19-4
5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

2: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

3: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

4: acetic acid / methanol / Inert atmosphere; Reflux

5: sodium cyanoborohydride / methanol / 3 h / 20 °C / Inert atmosphere

With water; nitric acid; acetic anhydride; boron trichloride; sodium cyanoborohydride; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: 1202920-36-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

: 1202921-19-4
5-(5-chloro-2,4-dihydroxyphenyl)-4-(cyclohexylamino)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

2: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

3: acetic acid / methanol / Inert atmosphere; Reflux

4: sodium cyanoborohydride / methanol / 3 h / 20 °C / Inert atmosphere

With water; boron trichloride; sodium cyanoborohydride; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm201155e