lobelanidine monoacetate

Base Information

• Chemical Name: lobelanidine monoacetate
• CAS No.: 1146626-22-3
• Molecular Formula: C₂₄H₃₁NO₃
• Molecular Weight: 381.515
• Mol file: 1146626-22-3.mol

Synonyms:

Chemical Property of lobelanidine monoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of lobelanidine monoacetate

There total 2 articles about lobelanidine monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

vinyl acetate (108-05-4,9003-20-7) + NSC 95097 (552-72-7) → lobelanidine monoacetate + lobelanidine monoacetate (1146626-22-3) + lobelanidine diacetate (1146626-27-8)

Guidance literature:

With pseudomonas fluorescens lipase; at 25 ℃; for 183h; optical yield given as %ee;

DOI:10.1016/j.bmc.2009.01.055

Reference yield: 23.0%

lobelanidine diacetate (1146626-27-8) → lobelanidine monoacetate (1146626-22-3) + NSC 95097 (552-72-7)

Guidance literature:

With Candida antarctica lipase B; In diethyl ether; at 50 ℃; pH=7.1; optical yield given as %ee; aq. phosphate buffer;

DOI:10.1016/j.bmc.2009.01.055

Reference yield:

lobelanidine monoacetate (1146626-22-3) → [(S)-2-[(2S,6R)-1-methyl-6-(2-oxo-2-phenylethyl)piperidin-2-yl]-1-phenylethyl acetate] (1125824-45-4)

Guidance literature:

With Jones reagent; In acetone; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2009.01.055

upstream raw materials:

lobelanidine diacetate

vinyl acetate

NSC 95097

Downstream raw materials:

[(S)-2-[(2S,6R)-1-methyl-6-(2-oxo-2-phenylethyl)piperidin-2-yl]-1-phenylethyl acetate]