C₁₇H₁₇F₃O₄

Base Information

• Chemical Name: C₁₇H₁₇F₃O₄
• CAS No.: 1123211-32-4
• Molecular Formula: C₁₇H₁₇F₃O₄
• Molecular Weight: 342.315
• Mol file: 1123211-32-4.mol

Synonyms:

Chemical Property of C₁₇H₁₇F₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₇F₃O₄

There total 7 articles about C₁₇H₁₇F₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,6S)-4-hydroxy-6-methylcyclohex-2-enone (931103-80-9) + R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → C17H17F3O4 (1123211-32-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 168h;

DOI:10.1021/np800667e

Reference yield:

C7H10O2 + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C17H17F3O4 (1123211-32-4) + C17H17F3O4 (1404477-70-8) + C17H17F3O4 (1404477-71-9) + C17H17F3O4 (1404477-69-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.833333h; Overall yield = 98 %; Overall yield = 33 mg; Inert atmosphere;

DOI:10.1002/ejoc.201200704

Reference yield:

4-methylcyclohexene (591-47-9) → C17H17F3O4 (1123211-32-4) + C17H17F3O4 (1404477-70-8) + C17H17F3O4 (1404477-71-9) + C17H17F3O4 (1404477-69-5)

Guidance literature:

Multi-step reaction with 6 steps

1: bromine / chloroform / 0 °C

2: potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 180 °C

3: palladium diacetate; p-benzoquinone; manganese(IV) oxide; lithium acetate dihydrate / pentane / 72 h / 20 °C

4: potassium carbonate; methanol

5: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

6: dmap; triethylamine / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

With methanol; dmap; manganese(IV) oxide; lithium acetate dihydrate; bromine; palladium diacetate; potassium carbonate; Dess-Martin periodane; triethylamine; p-benzoquinone; potassium hydroxide; In dichloromethane; chloroform; pentane; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;

DOI:10.1002/ejoc.201200704

upstream raw materials:

(4R,6S)-4-hydroxy-6-methylcyclohex-2-enone

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

1,4-diacetoxy-5-methylcyclohex-2-ene

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride