(1-Ethyl-1H-indol-3-yl)phenylmethanone

Base Information

• Chemical Name: (1-Ethyl-1H-indol-3-yl)phenylmethanone
• CAS No.: 713086-44-3
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.312
• Mol file: 713086-44-3.mol

Synonyms:

Chemical Property of (1-Ethyl-1H-indol-3-yl)phenylmethanone

Chemical Property:

• Density: 1.09

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-Ethyl-1H-indol-3-yl)phenylmethanone

There total 14 articles about (1-Ethyl-1H-indol-3-yl)phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-Ethylindole (10604-59-8) + carbon monoxide (201230-82-2) + phenylboronic acid (98-80-6) → (1-ethyl-1H-indol-3-yl)(phenyl)methanone (713086-44-3)

Guidance literature:

With pyridine; iodine; palladium diacetate; cesium fluoride; potassium hydroxide; In toluene; at 80 ℃; for 12h;

DOI:10.1021/cs5019106

Reference yield: 78.0%

N-Ethylindole (10604-59-8) + phenyl formate (1864-94-4) → (1-ethyl-1H-indol-3-yl)(phenyl)methanone (713086-44-3)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/cctc.201600433

Reference yield: 66.0%

N-Ethylindole (10604-59-8) + chloroform (67-66-3,8013-54-5) + phenylboronic acid (98-80-6) → (1-ethyl-1H-indol-3-yl)(phenyl)methanone (713086-44-3)

Guidance literature:

With dmap; iodine; palladium diacetate; potassium hydroxide; In toluene; at 80 ℃; for 12h;

DOI:10.1021/acs.joc.6b02711

upstream raw materials:

N-ethyl-N-methyl-2-(phenylethynyl)aniline

N-Ethylindole

Benzoylformic acid

2-methyl-1H-indole

Refernces

• 1、 Gao, Fei,Wang, Jiu-Tao,Liu, Lin-Lin,Ma, Na,Yang, Chao,Gao, Yuan,Xia, Wujiong. "Synthesis of carbonylated heteroaromatic compounds: Via visible-light-driven intramolecular decarboxylative cyclization of o -alkynylated carboxylic acids". . p. 8533 - 8536. Retrieved 2017/08/04.
• 2、 Gu, Li-Jun,Wang, Yu-Shen,Zhang, Hong-Tao,Tang, Huai-Jun,Li, Gan-Peng,Yuan, Ming-Long. "Palladium-Catalyzed Carbonylation of Indoles using Aryl Formates as Bifunctional Reagents: A Route to Indol-3-yl Aryl Ketones". . p. 2206 - 2209. Retrieved 2016/07/19.