1-Ethyl-1H-indole

Base Information

• Chemical Name: 1-Ethyl-1H-indole
• CAS No.: 10604-59-8
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Hs Code.: 2933990090
• NSC Number: 93082
• UNII: H03CX1P47U
• DSSTox Substance ID: DTXSID10293941
• Nikkaji Number: J45.621G
• Wikidata: Q63399063
• Mol file: 10604-59-8.mol

Synonyms:1-Ethyl-1H-indole;10604-59-8;1-Ethylindole;N-Ethylindole;1H-Indole, 1-ethyl-;Indole, 1-ethyl-;H03CX1P47U;NSC-93082;1H-Indole, ethyl-;N-ethyl-indole;NSC93082;NCIOpen2_001553;UNII-H03CX1P47U;SCHEMBL1629560;AMY2733;DTXSID10293941;MFCD00462230;NSC 93082;AKOS000406264;CS-0054225;FT-0649034;F87743;A801364;Q63399063;InChI=1/C10H11N/c1-2-11-8-7-9-5-3-4-6-10(9)11/h3-8H,2H2,1H

Chemical Property of 1-Ethyl-1H-indole

Chemical Property:

• Vapor Pressure: 0.029mmHg at 25°C
• Melting Point: 105°C
• Refractive Index: 1.56
• Boiling Point: 253.5 °C at 760 mmHg
• Flash Point: 107.1 °C
• PSA: 4.93000
• Density: 0.99 g/cm³
• LogP: 2.66120
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 145.089149355
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

1-Ethyl-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C=CC2=CC=CC=C21

Technology Process of 1-Ethyl-1H-indole

There total 42 articles about 1-Ethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

indole (120-72-9) + ethyl iodide (75-03-6) → N-Ethylindole (10604-59-8)

Guidance literature:

indole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

ethyl iodide; for 1h;

DOI:10.1039/C9OB00144A

Reference yield: 100.0%

indole (120-72-9) + ethyl bromide (74-96-4) → N-Ethylindole (10604-59-8)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1039/c4ob02170c

Reference yield: 99.0%

indole (120-72-9) → N-Ethylindole (10604-59-8)

Guidance literature:

indole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

ethyl halide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b03243

upstream raw materials:

N-vinylindole

N-ethyl-N-phenylamine

acetylene

N,N-diethylaniline

Downstream raw materials:

6-(1-ethyl-indol-3-yl)-2,3,4,5-tetrachloro-6-hydroxy-cyclohexa-2,4-dienone

1-(1-ethyl-1H-indol-3-yl)ethan-1-one

(2R,3R)-2-Benzyloxycarbonylamino-3-(1-ethyl-1H-indol-3-yl)-butyric acid

3-(1-ethylindol-3-yl)-4-hydroxybenzonitrile