5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

Base Information

Chemical Name:5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate
CAS No.:1354819-08-1
Molecular Formula:C₇H₈O₃S*C₂₀H₁₀ClF₅N₄O₃S₂
Molecular Weight:721.106
Hs Code.:

5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

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Chemical Property of 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

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Technology Process of 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

There total 7 articles about 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354818-80-6
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

: 104-15-4
toluene-4-sulfonic acid

: 1354819-08-1
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: In acetone; for 0.25h;

Reference yield:

: 61721-07-1
4-fluoro-3-(trifluoromethyl)phenol

: 1354819-08-1
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; acetic acid; N-iodo-succinimide / 3 h / 0 - 20 °C

2.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

3.2: 18 h / 20 °C

4.1: dichloromethane / 2 h

5.1: potassium hydroxide / water / 20 °C

6.1: acetone / 0.25 h

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; acetic acid; cesium fluoride; potassium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1354819-14-9
4-fluoro-2-iod-5-(trifluoromethyl)phenol

: 1354819-08-1
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

2.2: 18 h / 20 °C

3.1: dichloromethane / 2 h

4.1: potassium hydroxide / water / 20 °C

5.1: acetone / 0.25 h

With copper(l) iodide; cesium fluoride; potassium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;