5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Base Information

Chemical Name:5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide
CAS No.:1354818-80-6
Molecular Formula:C₂₀H₁₀ClF₅N₄O₃S₂
Molecular Weight:548.901
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

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Chemical Property of 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

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Technology Process of 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

There total 6 articles about 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide bis(trifluoroacetate)

: 1354818-80-6
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: With potassium hydroxide; In water; at 20 ℃;

Reference yield:

: 61721-07-1
4-fluoro-3-(trifluoromethyl)phenol

: 1354818-80-6
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; acetic acid; N-iodo-succinimide / 3 h / 0 - 20 °C

2.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

3.2: 18 h / 20 °C

4.1: dichloromethane / 2 h

5.1: potassium hydroxide / water / 20 °C

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; acetic acid; cesium fluoride; potassium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1354819-14-9
4-fluoro-2-iod-5-(trifluoromethyl)phenol

: 1354818-80-6
5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

2.2: 18 h / 20 °C

3.1: dichloromethane / 2 h

4.1: potassium hydroxide / water / 20 °C

With copper(l) iodide; cesium fluoride; potassium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;