Technology Process of C12H16O4
There total 10 articles about C12H16O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / methanol; diethyl ether / 18 h / 0 - 20 °C
2: hydrogenchloride / water / 0.5 h / 20 °C
3: lithium hydroxide / water
4: hydrogenchloride; Staphylococcus epidermis D-lactate dehydrogenase; Candida boidinii formate dehydrogenase; ethylenediaminetetraacetic acid; 2-hydroxyethanethiol; ammonium formate; NAD / water / 20 °C / pH 7 / Enzymatic reaction
5: thionyl chloride
With
hydrogenchloride; Candida boidinii formate dehydrogenase; thionyl chloride; ethylenediaminetetraacetic acid; Staphylococcus epidermis D-lactate dehydrogenase; NAD; ammonium formate; sodium hydride; 2-hydroxyethanethiol; lithium hydroxide;
In
methanol; diethyl ether; water;
DOI:10.1002/ejoc.201201506
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride / methanol; diethyl ether / 18 h / 0 - 20 °C
2: hydrogenchloride / water / 0.5 h / 20 °C
3: triethylamine / dichloromethane / 16 h / 0 - 20 °C
4: hydrogen; Rh(I) [(R,R)-Dipamp](COD) / methanol / 96 h / 20 °C / 3750.38 Torr / Inert atmosphere
5: lithium hydroxide / water; tetrahydrofuran
6: thionyl chloride
With
hydrogenchloride; thionyl chloride; Rh(I) [(R,R)-Dipamp](COD); hydrogen; sodium hydride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/ejoc.201201506
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide / water; tetrahydrofuran
2: thionyl chloride
With
thionyl chloride; lithium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1002/ejoc.201201506