Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Chemical Name:Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester
CAS No.:89388-04-5
Molecular Formula:C₂₂H₂₄N₂O₉P₂S₂
Molecular Weight:586.52
Hs Code.:

Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Chemical Property of Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Technology Process of Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

There total 5 articles about Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-98-5
thiophenol

: 89388-04-5
Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / triethylamine / diethyl ether / 2 h

2: 83 percent / LiOH

3: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

4: 80percent acetic acid

5: 94 percent / mesitylenedisulfonyl chloride

6: 15 equiv. isoamyl nitrite, acetic acid, pyridine / 24 h / Ambient temperature

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; acetic acid; triethylamine; isopentyl nitrite; In diethyl ether;
DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

: 67941-87-1
cyclohexylammonium S,S-diphenyl phosphorodithioate

: 89388-04-5
Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / mesitylenedisulfonyl chloride

2: 15 equiv. isoamyl nitrite, acetic acid, pyridine / 24 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; acetic acid; isopentyl nitrite;
DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

: 89387-96-2
S,S-diphenyl phosphoranilidodithioate

: 89388-04-5
Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / LiOH

2: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

3: 80percent acetic acid

4: 94 percent / mesitylenedisulfonyl chloride

5: 15 equiv. isoamyl nitrite, acetic acid, pyridine / 24 h / Ambient temperature

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; acetic acid; isopentyl nitrite;
DOI:10.1016/S0040-4039(00)94189-3