Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester
• CAS No.: 89388-01-2
• Molecular Formula: C₃₄H₃₃N₃O₇P₂S₃
• Molecular Weight: 753.797

Synonyms:

Chemical Property of Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester

Chemical Property:

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Technology Process of Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester

There total 5 articles about Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester (89387-98-4,89387-99-5) → Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester (89388-01-2)

Guidance literature:

With 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride;

DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

thiophenol (108-98-5) → Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester (89388-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / triethylamine / diethyl ether / 2 h

2: 83 percent / LiOH

3: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

4: 80percent acetic acid

5: 94 percent / mesitylenedisulfonyl chloride

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; acetic acid; triethylamine; In diethyl ether;

DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

S,S-diphenyl phosphoranilidodithioate (89387-96-2) → Dithiophosphoric acid O-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(phenylamino-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-ylmethyl] ester S,S'-diphenyl ester (89388-01-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / LiOH

2: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

3: 80percent acetic acid

4: 94 percent / mesitylenedisulfonyl chloride

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; acetic acid;

DOI:10.1016/S0040-4039(00)94189-3

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

S,S-diphenyl phosphoranilidodithioate

cyclohexylammonium S-phenyl phosphoranilidodithioate

Downstream raw materials:

Thiophosphoric acid O-[(2R,3S,5R)-2-(hydroxy-phenylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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