Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Chemical Name:Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester
CAS No.:89387-98-4
Molecular Formula:C₂₂H₂₄N₃O₆PS
Molecular Weight:489.489
Hs Code.:

Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Chemical Property of Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

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Technology Process of Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

There total 3 articles about Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-98-5
thiophenol

: 89387-98-4,89387-99-5
Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / triethylamine / diethyl ether / 2 h

2: 83 percent / LiOH

3: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

4: 80percent acetic acid

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; acetic acid; triethylamine; In diethyl ether;
DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

: Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

: 89387-98-4,89387-99-5
Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: With acetic acid; Yield given;
DOI:10.1016/S0040-4039(00)94189-3

Reference yield:

: 89387-96-2
S,S-diphenyl phosphoranilidodithioate

: 89387-98-4,89387-99-5
Phenyl-thiophosphoramidic acid O-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / LiOH

2: 91 percent / 2,4,6-triisopropylbenzenesulfonyl chloride, pyridine

3: 80percent acetic acid

With pyridine; lithium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; acetic acid;
DOI:10.1016/S0040-4039(00)94189-3