Technology Process of (7-Benzyl-7-aza-bicyclo[2.2.1]hept-1-yl)-acetic acid ethyl ester
There total 6 articles about (7-Benzyl-7-aza-bicyclo[2.2.1]hept-1-yl)-acetic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaBH3CN, CH3COOH / methanol / Ambient temperature
2: 1 N aq. HCl / 0.25 h
3: NaH / tetrahydrofuran / 1.) ice bath, 20 min, 2.) ice bath, 30 min; r.t., 1 h
4: neutral Al2O3 / dioxane / Heating
With
hydrogenchloride; aluminum oxide; sodium hydride; sodium cyanoborohydride; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jo00129a061
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1 N aq. HCl / 0.25 h
2: NaH / tetrahydrofuran / 1.) ice bath, 20 min, 2.) ice bath, 30 min; r.t., 1 h
3: neutral Al2O3 / dioxane / Heating
With
hydrogenchloride; aluminum oxide; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo00129a061
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaH / tetrahydrofuran / 1.) ice bath, 20 min, 2.) ice bath, 30 min; r.t., 1 h
2: neutral Al2O3 / dioxane / Heating
With
aluminum oxide; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo00129a061
