131511-13-2

Basic information

• Product Name: N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL
• Synonyms: N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL
• CAS NO: 131511-13-2
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.33274
• Mol File: 131511-13-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 374.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 9.66±0.20(Predicted)
• CAS DataBase Reference: N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL(131511-13-2)
• EPA Substance Registry System: N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL(131511-13-2)

Safety Data

• Hazardous Substances Data: 131511-13-2(Hazardous Substances Data)

Usage

General Description

N-Benzyl-4-aminocyclohexanone ethylene ketal is a chemical compound that is derived from benzylamine and cyclohexanone. It is commonly used as a reagent in organic synthesis and pharmaceutical research. N-BENZYL-4-AMINOCYCLOHEXANONE ETHYLENE KETAL is known for its unique structure which contains a cyclic amine and a ketal functional group. It has been studied for its potential applications as a building block in the synthesis of complex organic molecules and as a key intermediate in the production of pharmaceutical compounds. N-Benzyl-4-aminocyclohexanone ethylene ketal has also been investigated for its potential biological activities and pharmacological properties. Overall, this chemical compound has a range of potential applications in fields such as medicinal chemistry, material science, and agrochemical research.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 3287-99-8 benzylamine hydrochloride 
• 100-46-9 benzylamine 
• 230287-23-7 N-(1,4-dioxaspiro[4.5]decyl-7-idene)benzylamine 

Downstream Products

• 142009-99-2 4-(benzylamino)cyclohexane-1-one 
• 168893-04-7 N,N-dibenzyl-1,4-dioxaspiro[4.5]decan-8-amine 
• 1092768-82-5 C₂₄H₂₅NO₃S 
• 1119283-62-3 (trans)-N,N-dibenzyl-4-(4-methylpiperazin-1-yl)cyclohexanamine 
• 883195-12-8 C₂₅H₃₅N₃ 
• 1119283-64-5 C₁₁H₂₃N₃ 
• 1119283-66-7 C₁₆H₃₁N₃O₂ 
• 1119283-68-9 C₁₂H₂₅N₃ 
• 1119284-16-0 C₁₃H₂₅N₃O 
• 1119284-19-3 C₁₃H₂₇N₃ 
• 422507-45-7 4-benzylamino-1-trimethylsilyloxycyclohexane-1-carbonitrile 
• 187807-19-8 4-(benzylamino)cyclohex-1-encarbonitrile 

Relevant articles and documents

A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C-H amination and intramolecular Heck cascade between aryl iodides and functionalized amination reagents is reported, thereby providing a highly convergent access to the u

Organocatalytic Enantioselective Conia-Ene-Type Carbocyclization of Ynamide Cyclohexanones: Regiodivergent Synthesis of Morphans and Normorphans

Described herein is an organocatalytic enantioselective desymmetrizing cycloisomerization of arylsulfonyl-protected ynamide cyclohexanones, representing the first metal-free asymmetric Conia-ene-type carbocyclization. This method allows the highly efficient and atom-economical construction of a range of valuable morphans with wide substrate scope and excellent enantioselectivity (up to 97 % ee). In addition, such a cycloisomerization of alkylsulfonyl-protected ynamide cyclohexanones can lead to the divergent synthesis of normorphans as the main products with high enantioselectivity (up to 90 % ee). Moreover, theoretical calculations are employed to elucidate the origins of regioselectivity and enantioselectivity.

Synthesis of the tetracyclic ABCD ring systems of madangamines D-F

Synthesis of the tetracyclic cores of madangamines D-F was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.