2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide

Base Information

Chemical Name:2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide
CAS No.:83425-17-6
Molecular Formula:C₁₉H₂₂ClN₃O
Molecular Weight:343.856
Hs Code.:
DSSTox Substance ID:DTXSID001185716

Synonyms:2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide;DTXSID001185716;83425-17-6

Suppliers and Price of 2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:343.1451400
Heavy Atom Count:24
Complexity:405

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1NC(=O)C2=C(C=CC(=C2)Cl)N)CC3=CC=CC=C3

Technology Process of 2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide

There total 1 articles about 2-Amino-5-chloro-N-[1-(phenylmethyl)-4-piperidinyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.5%

: 4743-17-3
5-Chloroisatoic anhydride

: 50541-93-0
4-amino-1-benzylpiperidine

: 83425-17-6
1-benzyl-4-(2-amino-5-chlorobenzoylamino)piperidine

Guidance literature:: With TEA; In 1,4-dioxane; for 2h; Heating;
DOI:10.1248/cpb.34.1907

Reference yield: 88.7%

: 541-41-3
chloroformic acid ethyl ester

: 83425-17-6
1-benzyl-4-(2-amino-5-chlorobenzoylamino)piperidine

: 104260-18-6
1-ethoxycarbonyl-4-(2-ethoxycarbonylamino-5-chlorobenzoylamino)piperidine

Guidance literature:: at 93 ℃; for 3h;
DOI:10.1248/cpb.34.1907

Reference yield:

: 83425-17-6
1-benzyl-4-(2-amino-5-chlorobenzoylamino)piperidine

: 104260-16-4
6-Chloro-3-[1-(2-oxo-2-phenyl-ethyl)-piperidin-4-yl]-1H-quinazoline-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 88.7 percent / 3 h / 93 °C

2: 76.4 percent / KOH / ethanol / 3 h / Heating

3: 70.4 percent / 47percent aq. HBr / 8 h / Heating

4: TEA / methanol / Ambient temperature

With potassium hydroxide; TEA; hydrogen bromide; In methanol; ethanol;
DOI:10.1248/cpb.34.1907