C₂₀H₃₈O₃Si₂

Base Information

• Chemical Name: C₂₀H₃₈O₃Si₂
• CAS No.: 1298075-98-5
• Molecular Formula: C₂₀H₃₈O₃Si₂
• Molecular Weight: 382.691
• Mol file: 1298075-98-5.mol

Synonyms:

Chemical Property of C₂₀H₃₈O₃Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₃₈O₃Si₂

There total 1 articles about C₂₀H₃₈O₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate (213250-59-0) → C20H38O3Si2 (1298075-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; trichlorophosphate / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

3: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere

With pyridine; tetra-n-propylammonium perruthenate.; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; trichlorophosphate; In dichloromethane; toluene;

DOI:10.1021/ja201481j

Reference yield:

C20H38O3Si2 (1298075-98-5) → C45H82O3Si3

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2.25 h / -78 - 0 °C / Inert atmosphere

2.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling reaction;

DOI:10.1021/ja201481j

Reference yield:

C20H38O3Si2 (1298075-98-5) → 14-epi-2-methylene-1α,25(OH)2-6,7-dehydro-19-norvitamin D3 (1227058-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2.25 h / -78 - 0 °C / Inert atmosphere

2.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; tetrabutyl ammonium fluoride; diethylamine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling reaction;

DOI:10.1021/ja201481j

upstream raw materials:

methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate

Downstream raw materials:

14-epi-2-methylene-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

14-epi-2α-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

14-epi-2β-methyl-1α,25(OH)2-6,7-dehydro-19-norvitamin D3

14-epi-2α-methyl-1α,25-dihydroxy-19-norprevitamin D3