Technology Process of RX 811010
There total 9 articles about RX 811010 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: HCl / CH2Cl2 / 0.5 h / 0 °C
2: SnCl4 / 60 h / Ambient temperature
3: 1.) CH3ONa, 2.) HCl / 1.) CH3OH, 18 h, 2.) CH3OH, RT, 16 h
With
hydrogenchloride; sodium methylate; tin(IV) chloride;
In
dichloromethane;
DOI:10.1021/jm00146a013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) benzyltrimethylammonium chloride, 2.) KBr / 1.) benzene, reflux, 6 h, 2.) benzene, reflux, 4 h
2: HCl / CH2Cl2 / 0.5 h / 0 °C
3: SnCl4 / 60 h / Ambient temperature
4: 1.) CH3ONa, 2.) HCl / 1.) CH3OH, 18 h, 2.) CH3OH, RT, 16 h
With
hydrogenchloride; sodium methylate; tin(IV) chloride; benzyltrimethylammonium chloride; potassium bromide;
In
dichloromethane;
DOI:10.1021/jm00146a013
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaOH, KMnO4 / H2O / 48 h / Ambient temperature
2: SOCl2 / toluene / 1 h / 90 - 100 °C
3: aq. 33percent NH3 / dioxane / 1 h / 0 - 10 °C
4: P2O5 / toluene / 4 h / Heating
5: 1.) CH3ONa, 2.) HCl / 1.) CH3OH, 18 h, 2.) CH3OH, RT, 16 h
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium permanganate; thionyl chloride; sodium methylate; phosphorus pentoxide;
In
1,4-dioxane; water; toluene;
DOI:10.1021/jm00146a013
