Technology Process of (+/-)-2,3,6,7-tetrahydro-1-carbomethoxy-11β-(phenylthio)-16-methoxy-20,21-dinoraspidospermidin-8-one
There total 10 articles about (+/-)-2,3,6,7-tetrahydro-1-carbomethoxy-11β-(phenylthio)-16-methoxy-20,21-dinoraspidospermidin-8-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
toluene;
at 180 - 190 ℃;
for 24h;
in a sealed tube;
DOI:10.1021/ja00215a039
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / H2 / Raney-Ni / ethyl acetate / 18 h
2: 84 percent / POCl3 / 0.5 h / 0 °C
3: 79 percent / NaH / tetrahydrofuran / 0.25 h / from 0 deg C to room temp.
4: 100 percent / molecular sieves (3 Angstroem) / toluene / 23 h / 20 °C
5: 64 percent / diisopropylethylamine / toluene / 1 h / Heating
6: 98 percent / MCPBA, 10percent Na2CO3 / CH2Cl2; H2O / 1 h / 0 °C
7: 65 percent / 2,6-di-tert-butyl-4-methylpyridine, trifluoroacetic anhydride / toluene / 1 h / Heating
8: 88 percent / toluene / 24 h / 180 - 190 °C / in a sealed tube
With
2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; hydrogen; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; trichlorophosphate;
nickel;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/ja00215a039
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 55 percent / 0.5M HCl, LiCl / CuCl / H2O; various solvent(s) / 5 deg C, 3.5 h. then 20 deg C, 4 h.
2: 95 percent / H2 / Raney-Ni / ethyl acetate / 18 h
3: 84 percent / POCl3 / 0.5 h / 0 °C
4: 79 percent / NaH / tetrahydrofuran / 0.25 h / from 0 deg C to room temp.
5: 100 percent / molecular sieves (3 Angstroem) / toluene / 23 h / 20 °C
6: 64 percent / diisopropylethylamine / toluene / 1 h / Heating
7: 98 percent / MCPBA, 10percent Na2CO3 / CH2Cl2; H2O / 1 h / 0 °C
8: 65 percent / 2,6-di-tert-butyl-4-methylpyridine, trifluoroacetic anhydride / toluene / 1 h / Heating
9: 88 percent / toluene / 24 h / 180 - 190 °C / in a sealed tube
With
hydrogenchloride; 2,6-di-tert-butyl-4-methylpyridine; 3 A molecular sieve; hydrogen; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium chloride; trichlorophosphate;
nickel; copper(l) chloride;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/ja00215a039
