bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane

Base Information

• Chemical Name: bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane
• CAS No.: 145066-05-3
• Molecular Formula: C₁₆H₁₅F₂GeN₃
• Molecular Weight: 359.902
• Mol file: 145066-05-3.mol

Synonyms:

Chemical Property of bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane

There total 1 articles about bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis(4-fluorophenyl)(iodomethyl)methylgermane (145066-08-6) + sodium triazole (41253-21-8) → bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane (145066-05-3)

Guidance literature:

In N,N-dimethyl-formamide; byproducts: NaI; stirring mixt. of (FC6H4)2Ge(CH3)(CH2I) (5.73 mmol) and 1,2,4-triazole sodium salt (6.04 mmol) in DMF at 90°C for 3 h; cooling slurry to room temp., dilg. with H2O;; extg. with ether (3 x), washing combined exts. with satd. aq. NaCl-soln.; drying over anhydrous Na2SO4; removing solvent (reduced pressure); Kugelrohr distn. (170°C/0.1 torr); crystn. from (C2H5)2O/petroleum ether at -20°C; elem. anal.;;

DOI:10.1016/0022-328X(92)88005-4

upstream raw materials:

bis(4-fluorophenyl)(iodomethyl)methylgermane

sodium triazole