bis(4-fluorophenyl)(iodomethyl)methylgermane

Base Information

• Chemical Name: bis(4-fluorophenyl)(iodomethyl)methylgermane
• CAS No.: 145066-08-6
• Molecular Formula: C₁₄H₁₃F₂GeI
• Molecular Weight: 418.749
• Mol file: 145066-08-6.mol

Synonyms:

Chemical Property of bis(4-fluorophenyl)(iodomethyl)methylgermane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(4-fluorophenyl)(iodomethyl)methylgermane

There total 1 articles about bis(4-fluorophenyl)(iodomethyl)methylgermane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(chloromethyl)bis(4-fluorophenyl)methylgermane (145066-07-5) + sodium iodide (7681-82-5,24359-64-6,41927-88-2,115813-40-6) → bis(4-fluorophenyl)(iodomethyl)methylgermane (145066-08-6)

Guidance literature:

In acetone; byproducts: NaCl; stirring mixt. of (FC6H4)2Ge(CH3)(CH2Cl) (39.4 mmol) and NaI (118 mmol) in acetone for 21 h under reflux; cooling to room temp.;; pptn.; filtering off, washing with petroleum ether; removing solvent (reduced pressure); addn. of petroleum ether, keeping mixt. for 1 h at room temp.; filtering off ppt., removing solvent (reduced pressure); vac. distn. (Vigreux column); elem. anal.;;

DOI:10.1016/0022-328X(92)88005-4

Reference yield: 90.0%

bis(4-fluorophenyl)(iodomethyl)methylgermane (145066-08-6) + sodium triazole (41253-21-8) → bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane (145066-05-3)

Guidance literature:

In N,N-dimethyl-formamide; byproducts: NaI; stirring mixt. of (FC6H4)2Ge(CH3)(CH2I) (5.73 mmol) and 1,2,4-triazole sodium salt (6.04 mmol) in DMF at 90°C for 3 h; cooling slurry to room temp., dilg. with H2O;; extg. with ether (3 x), washing combined exts. with satd. aq. NaCl-soln.; drying over anhydrous Na2SO4; removing solvent (reduced pressure); Kugelrohr distn. (170°C/0.1 torr); crystn. from (C2H5)2O/petroleum ether at -20°C; elem. anal.;;

DOI:10.1016/0022-328X(92)88005-4

upstream raw materials:

(chloromethyl)bis(4-fluorophenyl)methylgermane

sodium iodide

Downstream raw materials:

bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane