1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime

Base Information

• Chemical Name: 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime
• CAS No.: 265105-63-3
• Molecular Formula: C₂₈H₂₈BrN₇O₂
• Molecular Weight: 574.48
• Mol file: 265105-63-3.mol

Synonyms:

Chemical Property of 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime

There total 10 articles about 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloronicotinoyl chloride (58757-38-3) → 5'-[4-amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-2,3,5,6-tetrahydro-[1,2']bipyridinyl-4-one O-(tetrahydro-pyran-4-yl)-oxime (265105-63-3)

Guidance literature:

Multi-step reaction with 5 steps

1: MgCl₂; Et₃N

2: aq. DMSO

3: ammonium acetate / 1,2-dichloro-ethane / 80 - 85 °C

4: formamide / 110 - 120 °C

5: dimethylsulfoxide / 100 °C

With ammonium acetate; dimethyl sulfoxide; triethylamine; magnesium chloride; In formamide; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(03)00642-5

Reference yield:

2-(3-bromobenzylidene)malononitrile (2972-74-9) → 5'-[4-amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-2,3,5,6-tetrahydro-[1,2']bipyridinyl-4-one O-(tetrahydro-pyran-4-yl)-oxime (265105-63-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / 1,2-dichloro-ethane / 80 - 85 °C

2: formamide / 110 - 120 °C

3: dimethylsulfoxide / 100 °C

With ammonium acetate; In formamide; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(03)00642-5

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 5'-[4-amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-2,3,5,6-tetrahydro-[1,2']bipyridinyl-4-one O-(tetrahydro-pyran-4-yl)-oxime (265105-63-3)

Guidance literature:

Multi-step reaction with 4 steps

1: glycine / ethanol; H₂O / 20 °C

2: ammonium acetate / 1,2-dichloro-ethane / 80 - 85 °C

3: formamide / 110 - 120 °C

4: dimethylsulfoxide / 100 °C

With ammonium acetate; glycine; In ethanol; water; formamide; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(03)00642-5

upstream raw materials:

formamide

6''-amino-4''-(3-bromo-phenyl)-4-(tetrahydro-pyran-4-yloxyimino)-3,4,5,6-tetrahydro-2H-[1,2';5',2'']terpyridine-5''-carbonitrile

5-(3-bromo-phenyl)-7-(6-chloro-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine

6-Chloronicotinoyl chloride