Technology Process of 6-phenyl-3b,4,5,6-tetrahydro-8H-imidazo<5,1-c>pyrrolo<1,2-a><1,4>benzodiazepine
There total 5 articles about 6-phenyl-3b,4,5,6-tetrahydro-8H-imidazo<5,1-c>pyrrolo<1,2-a><1,4>benzodiazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
methanol;
for 0.25h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDCI), Et3N / CH2Cl2 / 4 h / Ambient temperature
2: 100 percent / phosphorus oxychloride (POCl3) / 4 h / 40 °C
3: 96 percent / NaBH4 / aq. ethanol / 20 h / Ambient temperature
4: 78 percent / sodium hypophosphite hydrate / Pd/C / acetic acid / 1 h / Heating
5: 60.7 percent / methanol / 0.25 h / Heating
With
sodium tetrahydroborate; sodium hypophosphite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / NaBH4 / aq. ethanol / 20 h / Ambient temperature
2: 78 percent / sodium hypophosphite hydrate / Pd/C / acetic acid / 1 h / Heating
3: 60.7 percent / methanol / 0.25 h / Heating
With
sodium tetrahydroborate; sodium hypophosphite;
palladium on activated charcoal;
In
methanol; ethanol; acetic acid;
