15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester

Base Information

• Chemical Name: 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester
• CAS No.: 791805-20-4
• Molecular Formula: C₃₀H₅₀O₆
• Molecular Weight: 506.723
• Mol file: 791805-20-4.mol

Synonyms:

Chemical Property of 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester

There total 5 articles about 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester (791805-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / p-toluenesulfonic acid / dimethylformamide / 1.5 h / cooling

2: diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / Heating

With tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo0493020

Reference yield:

pentadecanolide (106-02-5,81031-90-5) → 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester (791805-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / Amberlyst A-15 / 48 h / Heating

2: chlorotrimethylsilane / CH₂Cl₂ / 1.33 h / 20 °C

3: diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / Heating

With chloro-trimethyl-silane; Amberlyst A-15; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0493020

Reference yield:

methyl 15-hydroxypentadecanoate (76529-42-5) → 15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecanoic acid methyl ester (791805-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorotrimethylsilane / CH₂Cl₂ / 1.33 h / 20 °C

2: diisopropylethylamine; tetrabutylammonium iodide / tetrahydrofuran / Heating

With chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0493020

upstream raw materials:

2-[(tetrahydro-2H-pyran-2-yloxy)methyl]phenylmethanol

15-chloromethoxy-pentadecanoic acid methyl ester

3,4-dihydro-2H-pyran

pentadecanolide

Downstream raw materials:

15-[2-(tetrahydro-pyran-2-yloxymethyl)-benzyloxymethoxy]-pentadecan-1-ol

(2-(15-allyloxy-pentadecyloxymethoxymethyl)-phenyl)-methanol

2-[2-(15-allyloxy-pentadecyloxymethoxymethyl)-benzyloxy]-tetrahydro-pyran

15-[2-(15-allyloxy-pentadecyloxymethoxymethyl)-benzyloxymethoxy]-pentadecan-1-ol