Mal-PEG2-t-butyl ester

Base Information

• Chemical Name: Mal-PEG2-t-butyl ester
• CAS No.: 518044-35-4
• Molecular Formula: C₁₇H₂₇NO₇
• Molecular Weight: 357.404
• Mol file: 518044-35-4.mol

Synonyms:

Chemical Property of Mal-PEG2-t-butyl ester

Chemical Property:

• Boiling Point: 465.1±35.0 °C(Predicted)
• PKA: -2.34±0.20(Predicted)
• Density: 1.161±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Mal-PEG3-t-butylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Mal-PEG3-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Technology Process of Mal-PEG2-t-butyl ester

There total 2 articles about Mal-PEG2-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxycarbonylmaleimide (55750-48-6) + tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) → tert-butyl 3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoate (518044-35-4)

Guidance literature:

With sodium hydrogencarbonate;

Reference yield:

C17H29NO8 → tert-butyl 3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoate (518044-35-4)

Guidance literature:

With zinc diacetate; toluene-4-sulfonic acid; hydroquinone; In toluene; at 20 ℃; Reflux;

DOI:10.1002/chem.200801237

Reference yield:

tert-butyl 3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoate (518044-35-4) → 3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoic acid (518044-40-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/c5ra06806a

upstream raw materials:

N-methoxycarbonylmaleimide

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

Downstream raw materials:

3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoic acid