Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

Base Information

Chemical Name:Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me
CAS No.:1364706-18-2
Molecular Formula:C₃₇H₄₂ClN₅O₈
Molecular Weight:720.222
Hs Code.:

Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO<sub>2</sub>Me

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Chemical Property of Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

Chemical Property:

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Technology Process of Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

There total 15 articles about Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₀ClN₅O₇*ClH

: 108-24-7
acetic anhydride

: 1364706-18-2
Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo202105v

Reference yield:

: 1364705-71-4
(6S,9S,12S)-methyl 12-(4-(benzyloxy)-3-iodobenzyl)-2,2,6,9-tetramethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

: 1364706-18-2
Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; 5.1: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v

Reference yield:

: 100-39-0
benzyl bromide

: 1364706-18-2
Ac-(cyclo-m,m)-[(3-Cl)FAAAY]-CO₂Me

Guidance literature:: Multi-step reaction with 12 steps

1.1: copper(II) sulfate; sodium hydroxide / water / 0.17 h / 60 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: thionyl chloride / 2 h / 20 °C / Inert atmosphere; Cooling

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

5.2: 16 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

7.2: 16 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

9.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

10.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

11.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; copper(II) sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 10.1: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v