5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide

Base Information

• Chemical Name: 5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide
• CAS No.: 1281681-33-1
• Molecular Formula: 2BrH*C₂₀H₂₂N₄OS
• Molecular Weight: 528.311
• Mol file: 1281681-33-1.mol

Synonyms:

Chemical Property of 5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

VP3.15dihydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide

There total 7 articles about 5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1-(4-morpholinethyl)-3-(N-phenylbenzimidoyl)thiourea (1281681-13-7) → 5-(4-morpholinethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide (1281681-33-1)

Guidance literature:

With bromine; In dichloromethane; ethyl acetate; at 0 - 4 ℃; for 3h;

DOI:10.1021/jm201463v

Reference yield: 51.0%

→ 5-(2-morpholinoethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide (1281681-33-1)

Guidance literature:

Reference yield:

benzoyl chloride (98-88-4) → 5-(4-morpholinethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide (1281681-33-1)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / ethyl acetate / 20 °C

2: thionyl chloride / 4 h / 135 °C

3: acetone / -15 °C

4: acetone / 0 °C

5: bromine / dichloromethane; ethyl acetate / 3 h / 0 - 4 °C

With thionyl chloride; bromine; triethylamine; In dichloromethane; ethyl acetate; acetone;

DOI:10.1021/jm201463v

upstream raw materials:

N-phenyl benzoyl amide

1-(4-morpholinethyl)-3-(N-phenylbenzimidoyl)thiourea

N-phenyl-benzimidoyl isothiocyanate

benzoyl chloride

Refernces

• 1、 -. "SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES". Page/Page column 11. . Retrieved 2012/09/11.