C₃₇H₄₈N₈O₅S

Base Information

Chemical Name:C₃₇H₄₈N₈O₅S
CAS No.:1421639-73-7
Molecular Formula:C₃₇H₄₈N₈O₅S
Molecular Weight:716.905
Hs Code.:

C<sub>37</sub>H<sub>48</sub>N<sub>8</sub>O<sub>5</sub>S

Synonyms:

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Chemical Property of C₃₇H₄₈N₈O₅S

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Technology Process of C₃₇H₄₈N₈O₅S

There total 18 articles about C₃₇H₄₈N₈O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 170157-60-5
(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

: 1421639-73-7
C₃₇H₄₈N₈O₅S

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / water; 1,4-dioxane / 4 h / pH 9

2.1: sodium hydroxide / water; ethanol / 1 h

3.1: sodium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / pH 9

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

5.1: trifluoroacetic acid / methanol / 0.33 h / Inert atmosphere

5.2: 3 h

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h

7.1: hydrazine hydrate / methanol

8.1: tert.-butylnitrite; hydrogenchloride / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / 3 h / -30 °C

9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h

With hydrogenchloride; tert.-butylnitrite; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3016987

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1421639-73-7
C₃₇H₄₈N₈O₅S

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid / 1 h / 20 - 25 °C

2.1: sodium carbonate / water; 1,4-dioxane / 4 h / pH 9

3.1: sodium hydroxide / water; ethanol / 1 h

4.1: sodium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / pH 9

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

6.1: trifluoroacetic acid / methanol / 0.33 h / Inert atmosphere

6.2: 3 h

7.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h

8.1: hydrazine hydrate / methanol

9.1: tert.-butylnitrite; hydrogenchloride / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / 3 h / -30 °C

10.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 0.5 h

With hydrogenchloride; tert.-butylnitrite; sulfuric acid; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3016987

Reference yield:

: 1177641-16-5
C₁₈H₂₀N₂O₄

: 1421639-73-7
C₃₇H₄₈N₈O₅S

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / pH 9

2.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

3.1: ethanol / 0.25 h / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / 4 h

5.1: triethylamine; dmap / dichloromethane / 6 h

6.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

7.2: 2 h / 0 - 20 °C / Inert atmosphere

8.1: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0.5 h

With dmap; lithium aluminium tetrahydride; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); palladium 10% on activated carbon; water; hydrogen; sodium hydride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm3016987