C₉H₁₀O₂

Base Information

• Chemical Name: C₉H₁₀O₂
• CAS No.: 1428945-39-4
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.177
• Mol file: 1428945-39-4.mol

Synonyms:

Chemical Property of C₉H₁₀O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₁₀O₂

There total 20 articles about C₉H₁₀O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,4-dihydroxybenzoate (2150-47-2) → C9H10O2 (1428945-39-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: trimethylaluminum / toluene / 1 h / -5 - 50 °C / Inert atmosphere

2.2: 20 h / Reflux; Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -80 °C / Inert atmosphere

3.2: 2 h / -80 - -15 °C / Inert atmosphere

4.1: lithium bromide; phenyllithium / tetrahydrofuran; dibutyl ether / 0.5 h / -75 - 20 °C / Inert atmosphere

4.2: 1.5 h / -75 - 20 °C / Inert atmosphere

4.3: 1 h / 20 °C / Inert atmosphere

5.1: dichloromethane / 15 h / 20 °C / Inert atmosphere

5.2: 6 h / Inert atmosphere

6.1: potassium hydroxide / ethanol / Inert atmosphere

With trimethylaluminum; tert.-butyl lithium; sodium hydride; phenyllithium; potassium hydroxide; lithium bromide; In tetrahydrofuran; ethanol; dichloromethane; dibutyl ether; toluene; pentane; 4.1: |Schlosser Modification / 4.2: |Schlosser Modification / 4.3: |Schlosser Modification;

DOI:10.1080/00397911.2012.681827

Reference yield:

methyl 2,4-bis<(tert-butyldimethylsilyl)oxy>benzoate (132297-26-8) → C9H10O2 (1428945-39-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trimethylaluminum / toluene / 1 h / -5 - 50 °C / Inert atmosphere

1.2: 20 h / Reflux; Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -80 °C / Inert atmosphere

2.2: 2 h / -80 - -15 °C / Inert atmosphere

3.1: lithium bromide; phenyllithium / tetrahydrofuran; dibutyl ether / 0.5 h / -75 - 20 °C / Inert atmosphere

3.2: 1.5 h / -75 - 20 °C / Inert atmosphere

3.3: 1 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 15 h / 20 °C / Inert atmosphere

4.2: 6 h / Inert atmosphere

5.1: potassium hydroxide / ethanol / Inert atmosphere

With trimethylaluminum; tert.-butyl lithium; phenyllithium; potassium hydroxide; lithium bromide; In tetrahydrofuran; ethanol; dichloromethane; dibutyl ether; toluene; pentane; 3.1: |Schlosser Modification / 3.2: |Schlosser Modification / 3.3: |Schlosser Modification;

DOI:10.1080/00397911.2012.681827

Reference yield:

4-hydroxysalicylic acid (89-86-1) → C9H10O2 (1428945-39-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / 96 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: trimethylaluminum / toluene / 1 h / -5 - 50 °C / Inert atmosphere

3.2: 20 h / Reflux; Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / -80 °C / Inert atmosphere

4.2: -80 - -15 °C / Inert atmosphere

4.3: -80 - 20 °C

5.1: dichloro bis(acetonitrile) palladium(II) / ethanol / 24 h / 20 °C / Inert atmosphere

6.1: dichloromethane / 15 h / 20 °C / Inert atmosphere

6.2: 6 h / Inert atmosphere

7.1: potassium hydroxide / ethanol / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); sulfuric acid; trimethylaluminum; tert.-butyl lithium; sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene; pentane;

DOI:10.1080/00397911.2012.681827

upstream raw materials:

2,4 dimethoxybenzoic acid

2-allyl-4,6-dimethoxybenzoic acid

2,4-Dimethoxy-6-(E-prop-1-enyl)benzoic acid

(E)-2,4-dihydroxy-6-(1-propenyl)benzoic acid isopropyl ester