1-Piperidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester
• CAS No.: 105706-78-3
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.321
• Mol file: 105706-78-3.mol

Synonyms:2-Vinyl-piperidine-1-carboxylic acid benzyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester

Chemical Property:

• Boiling Point: 353.1±41.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.132±0.06 g/cm3(Predicted)
• LogP: 3.30160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (3R)-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER (105706-76-1) → N-benzyloxycarbonyl-2-vinylpiperidine (105706-78-3)

Guidance literature:

With n-butyllithium; In hexane; benzene; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91346-8

Reference yield:

N-benzyloxycarbonyl-2-vinylpiperidine (105706-78-3) → N-chloroacetyl-2-vinylpiperidine (105706-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr-AcOH / CH₂Cl₂ / 4 h / Ambient temperature

2: 71 percent / K₂CO₃ / acetone / Ambient temperature

With hydrogen bromide; potassium carbonate; acetic acid; In dichloromethane; acetone;

DOI:10.1016/S0040-4020(01)91346-8

Reference yield:

N-benzyloxycarbonyl-2-vinylpiperidine (105706-78-3) → 2-vinylpiperidine (37848-70-7)

Guidance literature:

With hydrogen bromide; acetic acid; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91346-8 DOI:10.1002/jccs.199800046

upstream raw materials:

Methyltriphenylphosphonium bromide

(3R)-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Downstream raw materials:

2-vinylpiperidine

N-chloroacetyl-2-vinylpiperidine

Refernces

• 1、 Mori, Miwako,Kanda, Nana,Oda, Izumi,Ban, Yoshio. "New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond". . p. 5465 - 5474. Retrieved 2007/10/02.