3-Pyridinecarboxylic acid, 5-(benzoylamino)-1,4,5,6-tetrahydro-2-methyl-4-(4-nitrophenyl)-6-oxo-, ethyl ester, trans-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 5-(benzoylamino)-1,4,5,6-tetrahydro-2-methyl-4-(4-nitrophenyl)-6-oxo-, ethyl ester, trans-
CAS No.:105707-19-5
Molecular Formula:C₂₂H₂₁N₃O₆
Molecular Weight:423.425
Hs Code.:
Mol file:105707-19-5.mol

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 5-(benzoylamino)-1,4,5,6-tetrahydro-2-methyl-4-(4-nitrophenyl)-6-oxo-, ethyl ester, trans-

Chemical Property:

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Technology Process of 3-Pyridinecarboxylic acid, 5-(benzoylamino)-1,4,5,6-tetrahydro-2-methyl-4-(4-nitrophenyl)-6-oxo-, ethyl ester, trans-

There total 3 articles about 3-Pyridinecarboxylic acid, 5-(benzoylamino)-1,4,5,6-tetrahydro-2-methyl-4-(4-nitrophenyl)-6-oxo-, ethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 7152-75-2,57427-80-2,57427-96-0
4-(4-nitrobenzylidene)-2-phenyl-5(4H) oxazolone

: 626-34-6,7318-00-5,41867-20-3
ethyl aminocrotonate

: ethyl trans-2-methyl-4-(4-nitrophenyl)-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylate

: 105707-19-5,105707-20-8
ethyl cis-2-methyl-4-(4-nitrophenyl)-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: In neat (no solvent); at 180 ℃; for 1.5h;
DOI:10.1007/s10593-021-02980-w

Reference yield:

: 7152-75-2,57427-80-2,57427-96-0
(Z)-2-phenyl-4-(4-nitrobenzylidene)-(4H)-1,3-oxazol-5-one

: 626-34-6,7318-00-5,41867-20-3
ethyl aminocrotonate

: 105707-19-5,105707-20-8
ethyl cis-2-methyl-4-(4-nitrophenyl)-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: In chlorobenzene; Heating;

Reference yield:

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 555-16-8
4-nitrobenzaldehdye

: ethyl trans-2-methyl-4-(4-nitrophenyl)-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylate

: 105707-19-5,105707-20-8
ethyl cis-2-methyl-4-(4-nitrophenyl)-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: polyphosphoric acid

2: neat (no solvent) / 1.5 h / 180 °C

With polyphosphoric acid; In neat (no solvent);
DOI:10.1007/s10593-021-02980-w