(2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Base Information

• Chemical Name: (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)
• CAS No.: 1266348-22-4
• Molecular Formula: C₃₄H₃₀O₉
• Molecular Weight: 582.607
• Mol file: 1266348-22-4.mol

Synonyms:

Chemical Property of (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

There total 5 articles about (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 4-(4-formylphenoxy)benzaldehyde (2215-76-1) → (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one) (1266348-22-4)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

DOI:10.1007/s12272-010-1205-2

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one) (1266348-22-4)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; dimethylaminoacetic acid; caesium carbonate / 1,4-dioxane / 24 h / Reflux; Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

3: pyridinium chlorochromate / dichloromethane / 2 h / Molecular sieve; Inert atmosphere; Reflux

4: potassium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

With copper(l) iodide; lithium aluminium tetrahydride; dimethylaminoacetic acid; caesium carbonate; pyridinium chlorochromate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1: Ullmann condensation / 4: Claisen-Schmidt condensation;

DOI:10.1007/s12272-010-1205-2

Reference yield:

4,4'-oxybis(ethyl benzoate) (3096-86-4) → (2E,2'E)-3,3'-(4,4'-oxybis(4,1-phenylene))-bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one) (1266348-22-4)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

2: pyridinium chlorochromate / dichloromethane / 2 h / Molecular sieve; Inert atmosphere; Reflux

3: potassium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

With lithium aluminium tetrahydride; pyridinium chlorochromate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 3: Claisen-Schmidt condensation;

DOI:10.1007/s12272-010-1205-2

upstream raw materials:

Ethyl 4-hydroxybenzoate

2-hydroxy-4,6-dimethoxyacetophenone

4-(4-formylphenoxy)benzaldehyde

4,4'-oxy-bis(4,1-phenylene) dimethanol