2215-76-1Relevant articles and documents
Bis-Benzyl-Tetrahydroisoquinoline Derivatives As Therapeutics For Filovirus
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Paragraph 0058; 0059, (2019/09/20)
Bis-benzyl-tetrahydroisoquinoline analogs that are derivatives of the cyclic products tetrandrine (TETN) and cepharanthine (CEPH). The analogs indicate activity against filovirus infections, including the type species Marburg virus (MARV) and Ebola virus (EBOV).
Styrene-based compound and preparation method and application thereof
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, (2018/07/15)
The invention discloses a styrene-based compound, which is at least a 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound of the following structural formula. The invention also discloses a preparation method and application of the 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound of the structural formula. The 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound disclosed by the invention is used for inhibiting the abnormal growth of B-cells by lowering AKT/mTOR signal conduction. The formula is shown in the specification.
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors
Yang, Fengzhi,Xie, Fangzhou,Zhang, Ying,Xia, Yu,Liu, Wenlu,Jiang, Faqin,Lam, Celine,Qiao, Yixue,Xie, Dongsheng,Li, Jianqi,Fu, Lei
, p. 2166 - 2170 (2017/04/27)
Known PTP1B inhibitors with bis-anionic moieties exhibit potent inhibitory activity, good selectivity, however, they are incapable of penetrating cellular membranes. Based upon our finding of a new pharmacophoric group in inhibition of PTP1B and the struc