2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid
• CAS No.: 130622-07-0
• Molecular Formula: C₁₅H₂₈N₂O₆S
• Molecular Weight: 364.463
• Mol file: 130622-07-0.mol

Synonyms:

Chemical Property of 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid

Chemical Property:

• Boiling Point: 535.6±50.0 °C(Predicted)
• PKA: 3.58±0.10(Predicted)
• Density: 1.176±0.06 g/cm3(Predicted)

Purity/Quality:

99%+ ^*data from raw suppliers

Di-Boc-S-(2-aminoethyl)-L-cysteine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid

There total 4 articles about 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid methyl ester → 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid (130622-07-0)

Guidance literature:

With potassium trimethylsilonate; In dichloromethane;

DOI:10.1016/S0960-894X(03)00578-X

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid (130622-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaHCO₃ / methanol

2: pyridine

3: Cs₂CO₃ / dimethylformamide

4: KOSiMe₃ / CH₂Cl₂

With pyridine; potassium trimethylsilonate; sodium hydrogencarbonate; caesium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00578-X

Reference yield:

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 2-tert-butoxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfanyl)-propionic acid (130622-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: Cs₂CO₃ / dimethylformamide

3: KOSiMe₃ / CH₂Cl₂

With pyridine; potassium trimethylsilonate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00578-X

upstream raw materials:

di-tert-butyl dicarbonate

2-(N-tert-butoxycarbonylamino)ethanol

2-(tert-butoxycarbonylamino)ethyl methanesulfonate

Refernces