3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide

Base Information

• Chemical Name: 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide
• CAS No.: 1422961-59-8
• Molecular Formula: C₂₁H₁₈ClFN₂O₄S
• Molecular Weight: 448.902
• Mol file: 1422961-59-8.mol

Synonyms:

Chemical Property of 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide

There total 2 articles about 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxymethylpyridin (100-55-0) → 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide (1422961-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 150 °C

2: ammonium acetate / methanol / 8 h / Reflux

With ammonium acetate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1002/ddr.21024

Reference yield:

3-oxotetrahydrothiophene dioxide (17115-51-4) + pyridine-3-ylmethyl-3-oxobutanoate (50899-05-3) + 2-fluoro-3-chlorobenzaldehyde (85070-48-0) → 3-pyridylmethyl 7-(2-fluoro-3-chlorophenyl)-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylate-1,1-dioxide (1422961-59-8)

Guidance literature:

With ammonium acetate; In methanol; for 8h; Reflux;

DOI:10.1002/ddr.21024

upstream raw materials:

3-oxotetrahydrothiophene dioxide

pyridine-3-ylmethyl-3-oxobutanoate

2-fluoro-3-chlorobenzaldehyde

3-hydroxymethylpyridin