4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one

Base Information

• Chemical Name: 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one
• CAS No.: 35113-43-0
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.295
• Mol file: 35113-43-0.mol

Synonyms:

Chemical Property of 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one

There total 4 articles about 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 3-(4-methoxyphenyl)isoxazol-5(4H)-one (31709-47-4) → 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one (35113-43-0)

Guidance literature:

With piperidine; In isopropyl alcohol; at 50 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201410933

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one (35113-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 80 °C / Inert atmosphere; Reflux

2: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 20 h / 22 °C / Inert atmosphere

3: piperidine / isopropyl alcohol / 2 h / 50 °C / Inert atmosphere

With piperidine; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; water; isopropyl alcohol; mineral oil;

DOI:10.1002/anie.201410933

Reference yield:

ethyl 4-methoxybenzoylacetate (2881-83-6) → 4-benzylidene-3-(4-methoxy-phenyl)-4H-isoxazol-5-one (35113-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; potassium carbonate / ethanol; water / 20 h / 22 °C / Inert atmosphere

2: piperidine / isopropyl alcohol / 2 h / 50 °C / Inert atmosphere

With piperidine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; isopropyl alcohol;

DOI:10.1002/anie.201410933

upstream raw materials:

benzaldehyde

3-(4-methoxy-phenyl)-2H-isoxazol-5-one

1-(4-methoxyphenyl)ethanone

ethyl 4-methoxybenzoylacetate

Downstream raw materials:

{[3-(4-methoxy-phenyl)-5-oxo-2,5-dihydro-isoxazol-4-yl]-phenyl-methyl}-phosphonic acid dimethyl ester